Oral Mucosal Lesions

Oral lesions afflict children and adults, and the pharmacist may be the first point of contact regarding treatment. The prevalence of many oral lesions depends significantly on individual characteristics. Thus, prevalence rates should be based on studies of general populations and be stratified by risk factors for the specific lesion. These factors include sex, age, race/ethnicity, tobacco use, and use of removable dentures.

One of the preferred treatment options for oral mucosal lesions (eg, leukoplakia and lichen planus) is excision, with or without the use of a coverage agent. Platelet-rich fibrin (PRF) membranes are popular fibrin scaffolds with entrapped platelets that release various growth factors and cytokines to support and enhance wound healing. The aim of the present report was to describe the technique, postoperative wound care, and clinical results of PRF membrane grafting after excision of superficial potentially malignant oral lesions.

Autologous PRF membrane was fabricated and grafted over 26 wounds created by excision of small, superficial, potentially malignant lesions of oral mucosa (or fiberotomy in cases of oral submucous fibrosis) and assessed clinically at 7, 15, 30, and 60 days.